RP Physiology and Genetics
Abstract
Introduction
0.1
Retinal Communication Performance During Disease
0.2
Transcriptomic Profile of RP in Retinal Bipolar Cells
1
Retinal Communication During Blindness
1.1
Introduction
1.2
Methods
1.2.1
Data Collection and Preparation
1.2.2
Direct Method for Mutual Information
1.2.3
SPIKE Distance and Fano Factor
1.3
Results
1.3.1
Mesopic Vision Worsens with Degeneration
1.3.2
Cone Vision is Maintained with Degeneration
1.3.3
Nature Induces More Informative Responses
1.4
Discussion
1.4.1
Potential for Useful Vision Restoration
1.4.2
Naturalistic Stimuli
1.4.3
Limitations and Future Directions
2
Transcriptomic Profile of RP in Retinal Bipolar Cells
2.1
Introduction
2.2
Methods
2.2.1
Model Specifications
2.3
Results
2.3.1
Differential Genes Induced by Degeneration, Treatment, Treatment Time
2.4
Discussion
3
Conclusion
Supplemental Figures
References
Duke University
Department of Statistical Science
A Statistical Analysis of Inherited Blindness: Physiological and Genetic Assays
Supplemental Figures
Figure 3.1: fig caption
Figure 3.2: fig caption
