Chapter 9 Previous line

Previous line identifier is [pl]

9.1 Definition

Instrument previous line refers to any anticancer treatment received, either for a prior cancer or for the current cancer, before the current line.

The current line is the most recently administered one that contains immune checkpoint inhibitors. It can be ongoing at the time of index cardiotoxicity, or may have been interrupted.

9.2 Abbreviations

Here is a list of abbreviations used in several variables in the demo instrument.

Abbreviation(s)	Feature
atez avel cemi durv nivo ipil pemb trem	Standardized 4-character abbreviations of immune checkpoint inhibitors Atezolizumab, avelumab, cemiplimab, durvalumab, nivolumab, ipilimumab, pembrolizumab, tremelimumab
pd1 pdl1 ctla4	When drug name is not know, standardized abbreviations related to ICI class. Anti-PD1, anti-PD-L1, anti-CTLA4 Also pd1_other, pdl1_other, and ctla4_other to refer to an ICI from a class that is not in the aforementioned list (e.g. a new anti-PD1)