Chapter 5 Tract-Based Spatial Statistics

The ENIGMA DTI pipeline provides tools to extract whole-brain average and regional measurements from DTI images including FA, AD, RD and MD. The pipeline has been used successfully across sites worldwide and shown to extract reliable and heritable measures from diffusion imaging. Included in the analyses is an FA-template created from multiple high resolution datasets to better accommodate registrations to a standard atlas than current existing tools.

subjectID area FA MD RD AD
sub-001 ACR 0.46381 0.00078 0.00057 0.00120
sub-001 ACR-L 0.45272 0.00078 0.00058 0.00119
sub-001 ACR-R 0.47456 0.00078 0.00057 0.00121
sub-001 ALIC 0.59563 0.00073 0.00045 0.00128
sub-001 ALIC-L 0.60193 0.00071 0.00044 0.00126
sub-001 ALIC-R 0.59015 0.00074 0.00046 0.00129
sub-001 Average 0.50334 0.00077 0.00056 0.00120
sub-001 BCC 0.65101 0.00085 0.00046 0.00161
sub-001 CC 0.70971 0.00080 0.00039 0.00163
sub-001 CGC 0.67421 0.00074 0.00042 0.00137
sub-001 CGC-L 0.70638 0.00072 0.00038 0.00141
sub-001 CGC-R 0.63454 0.00075 0.00046 0.00134
sub-001 CGH 0.52390 0.00072 0.00049 0.00118
sub-001 CGH-L 0.46359 0.00076 0.00055 0.00119
sub-001 CGH-R 0.58681 0.00067 0.00042 0.00118
sub-001 CR 0.51897 0.00077 0.00053 0.00125
sub-001 CR-L 0.51274 0.00077 0.00053 0.00123
sub-001 CR-R 0.52478 0.00077 0.00053 0.00126
sub-001 CST 0.59199 0.00067 0.00043 0.00115
sub-001 CST-L 0.59051 0.00069 0.00044 0.00117
sub-001 CST-R 0.59359 0.00066 0.00042 0.00112
sub-001 EC 0.48503 0.00077 0.00055 0.00122
sub-001 EC-L 0.47797 0.00076 0.00055 0.00119
sub-001 EC-R 0.49210 0.00078 0.00055 0.00124
sub-001 FX 0.51324 0.00142 0.00102 0.00223
sub-001 FX/ST-L 0.58006 0.00077 0.00050 0.00131
sub-001 FX/ST-R 0.67751 0.00074 0.00043 0.00138
sub-001 FXST 0.62376 0.00076 0.00047 0.00134
sub-001 GCC 0.71197 0.00079 0.00038 0.00161
sub-001 IC 0.66695 0.00073 0.00040 0.00138
sub-001 IC-L 0.65778 0.00073 0.00041 0.00139
sub-001 IC-R 0.67570 0.00072 0.00039 0.00138
sub-001 IFO 0.51742 0.00077 0.00052 0.00126
sub-001 IFO-L 0.50033 0.00078 0.00055 0.00125
sub-001 IFO-R 0.53756 0.00076 0.00050 0.00127
sub-001 PCR 0.54621 0.00080 0.00054 0.00132
sub-001 PCR-L 0.52363 0.00081 0.00057 0.00129
sub-001 PCR-R 0.56364 0.00079 0.00052 0.00134
sub-001 PLIC 0.73021 0.00071 0.00034 0.00144
sub-001 PLIC-L 0.72760 0.00071 0.00034 0.00144
sub-001 PLIC-R 0.73272 0.00071 0.00034 0.00145
sub-001 PTR 0.63715 0.00079 0.00047 0.00143
sub-001 PTR-L 0.61975 0.00081 0.00049 0.00144
sub-001 PTR-R 0.65356 0.00078 0.00046 0.00142
sub-001 RLIC 0.67202 0.00075 0.00041 0.00143
sub-001 RLIC-L 0.63597 0.00079 0.00046 0.00146
sub-001 RLIC-R 0.70966 0.00071 0.00037 0.00140
sub-001 SCC 0.79870 0.00076 0.00030 0.00168
sub-001 SCR 0.56709 0.00074 0.00048 0.00127
sub-001 SCR-L 0.57448 0.00072 0.00046 0.00126
sub-001 SCR-R 0.55994 0.00075 0.00049 0.00128
sub-001 SFO 0.52257 0.00072 0.00048 0.00118
sub-001 SFO-L 0.53181 0.00072 0.00048 0.00119
sub-001 SFO-R 0.51284 0.00071 0.00049 0.00117
sub-001 SLF 0.55936 0.00076 0.00050 0.00128
sub-001 SLF-L 0.56393 0.00075 0.00049 0.00127
sub-001 SLF-R 0.55489 0.00077 0.00051 0.00129
sub-001 SS 0.58394 0.00081 0.00051 0.00141
sub-001 SS-L 0.54821 0.00085 0.00056 0.00144
sub-001 SS-R 0.61730 0.00077 0.00047 0.00138
sub-001 UNC 0.52642 0.00091 0.00061 0.00151
sub-001 UNC-L 0.48568 0.00097 0.00068 0.00154
sub-001 UNC-R 0.56402 0.00087 0.00056 0.00148

5.1 Files

List of files will include DTI measures from each of the regions of interest:

  • enigma-FA.csv
  • enigma-RD.csv
  • enigma-MD.csv
  • enigma-AD.csv